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KMID : 0603520000050010001
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 1 p.1 ~ p.6
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Peroxynitrite Scavenging Activity of Phloroglucinol from Ecklonia stolonifera
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Chung Hae-Young
Choi Hye-Rhi
Park Hye-Jin
Choi Jae-Sue
Choi Won-Chul
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Abstract
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Peroxynitrite (ONOO-), formed by the reaction of superoxide (O2-) and nitric oxide (NO), is a cytotoxic species that can oxidize several cellular components such as proteins, lipids, and DNA. It has been implicated in diseases such as cancer, Alzheimer´s disease, rheumatoid arthritis, and atherosclerosis. Due to the lack of endogenous enzymes responsible for ONOO- inactivation, developing a specific ONOO- scavenger is considerably important. The aim of this study was to evaluate the ability of phloroglucinol isolated from E. stolonifera to scavenge ONOO- and to protect cells against ONOO-. Phloroglucinol was found to be as a potent ONOO- scavenger. The data demonstrated that phloroglucinol led to decrease ONOO- -mediated nitration of tyrosine through electron donation. Phloroglucinol provided cytoprotection from cell damage induced by ONOO-.
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KEYWORD
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Peroxynitrite, scavenging activity, phloroglucinol, Nitrotyrosine, Cytoprotection, Smooth muscle cells
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